MedicoCompetente.it

FRANCO CANGIANI

Provenienza

Torino

Professione

Medico del Lavoro Competente

Messaggi

224

• Re: Polveri di legno
• (21/12/2010 22:18)

jolly il 21/12/2010 01:05 ha scritto:


Forse una via puoi trovarla nella letteratura scientifica sull'argomento (ma non quelle di stato, siamo medici, in medline ci sono autorevoli studi che ovviamente non fanno riferimento ai tlv ma a studi longitudinali). Non ho dati su minori. (io penso che la storia della non dose soglia lascia il tempo che trova nel valutare il prefigurarsi del rischio per la salute ma è solo un "nel più ci sta il meno"; meglio confrontarsi con esposizione nella popolazione generale).
Saluti

Acta Otorhinolaryngol Ital. 2004 Aug;24(4):199-203.

Adenocarcinoma of ethmoid sinus: an occupational disease.
Bimbi G, Saraceno MS, Riccio S, Gatta G, Licitra L, Cantù G.

Head and Neck Surgery Department, National Cancer Institute, Milan, Italy.

Abstract
Sinonasal tumours, particularly those of ethmoidal origin, are rare neoplasms, of which adenocarcinoma is the most frequent histotype in Europe. The association between sinonasal malignancies and exposure to wood or leather dusts has been widely documented, however, the precise tumour site and histology has seldom been reported. In the present study, exposure to wood or leather dusts was investigated in 499 patients diagnosed with sinonasal tumours, who were treated at the Head and Neck Surgery Department of the National Cancer Institute of Milan, Italy, between 1987 and 2001. The original tumour site and histology were carefully assessed. Of the 499 patients evaluated, 249 had ethmoidal tumours; 124 of which adenocarcinomas, affecting 115 males; 9 females. Of the males with adenocarcinoma, 90.4% had been exposed to wood or leather dusts; 16.3% of these had only been exposed for a short time and long before onset of the disease (median exposure 11 years; median latency 31 years). Of the remaining 125 patients with ethmoidal tumours other than adenocarcinomas, only 2 (1.6%) had ever been exposed to these dusts. Non-ethmoidal sinonasal tumours were seen in 250 cases; 17 of these (6.8%) were adenocarcinomas; no exposure to wood or leather dusts was reported in any of these patients. Ethmoid proved to be the sinonasal site affected by adenocarcinomas induced by exposure to wood or leather dusts. Even brief exposure, which may have occurred a very long time before onset of the disease, seems to be sufficient to increase the incidence of this tumour type. No significant correlation was observed between exposure and either non-ethmoidal sinonasal neoplasms or ethmoidal tumours other than adenocarcinomas.

PMID: 15688904 [PubMed - indexed for MEDLINE]






Se è tipo questo siamo fritti....

FRANCO CANGIANI

Provenienza

Torino

Professione

Medico del Lavoro Competente

Messaggi

224

• Re: Polveri di legno
• (21/12/2010 22:37)

Chiedere al ministero della pubblica istruzione istruzioni? O richiedere allo spresal di competenza che si esprima formalmente?

jolly

Provenienza

Pisa

Professione

Medico del Lavoro

Messaggi

66

• Re: Polveri di legno
• (22/12/2010 13:07)

FRANCO CANGIANI il 21/12/2010 10:23 ha scritto:
Niente io non mi prendo la briga di dire che il rischio per la salute non esiste.....altri consigli?

Credo che i ragazzi non lavorino direttamente alle macchine?
E' possibile cautelativamente dare idonei dpi?

paraquat

Provenienza

Cagliari

Professione

Medico del Lavoro Competente

Messaggi

102

• Re: Polveri di legno
• (22/12/2010 19:39)

Vi ricordo che i tumori naso sinusali sono ad alta frazione eziologica.

Un po' di bibliografia:

Barbieri PG, Lombardi S, Candela A, Festa R. Il Registro Neoplasie Naso-sinusali della provincia di Brescia. Epidemiol Prev 2003; 27 (4): 215-220.

Demers AP, Koveginas M, Boffetta P, et al. Wood dust and sino-nasal cancer: pooled reanalysis of twelve case-control studies. Am J Ind Med, 1995, 28: 151-166.

International Agency for Research on Cancer. World Health Organization. Iarc monographs on the evaluation of carcinogenic risks to humans. Wood dust and Formaldehyde, volume 26, 1995.

Gordon I, Boffetta P, Demers PA. A case study comparing a meta-analysis and a pooled analysis of
studies of sinonasal cancer among wood workers. Epidemiology. 1998 Sep;9(5):518-24

Iaia TE, Farina G, Ferraro MT, Miceli GB, Mugnaini E, Papaleo B, Battista G. A series of cases of
sinonasal cancer among shoemakers and tannery workers Epidemiol Prev. 2004 May-
Jun;28(3):169-73

International Agency for Research on Cancer. World Health Organization. Iarc monographs on the evaluation of carcinogenic risks to humans. Chromium, Nickel and Welding, volume 49, 1990.

International Information System on Occupational Exposure to Carcinogen. Occupational exposure to carcinogens in Italy in 1990-93. Carex/draft March 19, 1998.

Leclerc A, Luce D, Demers AP, et al. Sinonasal cancer on occupation.Results from the reanalysis of twelve case-control studies. Am J Ind Med, 1997, 31: 153-165.

Luce D, Leclerc A, Begin D, Demers PA, Gerin M, Orlowski E, Kogevinas M, Belli S, Bugel I, Bolm- Audorff U, Brinton LA, Comba P, Hardell L, Hayes RB, Magnani C, Merler E, Preston-Martin S, Vaughan TL, Zheng W, Boffetta P. Sinonasal cancer and occupational exposures: a pooled analysis of 12 case-control studies. Cancer Causes Control. 2002 Mar;13(2):147-57

Mastrangelo G, Fedeli U, Fadda E, Milan G, Lange JH. Epidemiologic evidence of cancer risk in textile industry workers: a review and update. Toxicol Ind Health. 2002 May;18(4):171-81

Mirabelli D, Kauppinen T. Occupational exposures to carcinogens in Italy: an update of CAREX database. Int J Occup Environ Health. 2005 Jan-Mar;11(1):53-63

Pelausa EO, Fortier MAG. Schneiderian papillomi of the nose and paranasal sinuose: the University of Ottawa experience. J Otolaryngol 1992; 21:9-15.

Shimizu H, Hozawa J, Saito H, et al. Chronic sinusitis and woodworking as risk factors for cancer of the maxillary sinus in the northeast Japan. Laryngoscope 1989; 99: 58-61.

t’Mannetje A, Kogevinas M, Luce D, et al. Sinonasal cancer, occupation and tobacco smoking in european women and men. Am J Ind Med 1999; 36: 101-107.

Teschke K, Morgan MS, Checkoway H, Franklin G, Spinelli JJ, van Belle G, Weiss NS. Surveillance of nasal and bladder cancer to locate sources of exposure to occupational carcinogens. Occup Environ Med. 1997 Jun;54(6):443-51

Van den Oever R. Occupational exposure to dust and sinonasal cancer. An analysis of 386 cases reported to the N.C.C.S.F. Cancer Registry. Acta Otorhinolaryngol Belg. 1996;50(1):19-24

Kauppinen T, Toikkanen J, Pedersen D, Young R, Ahrens W, Boffetta P, Hansen J, Kromhout H,
Maqueda Blasco J, Mirabelli D, de la Orden-Rivera V, Pannett B, Plato N, Savela A, Vincent R,
Kogevinas M. Occupational exposure to carcinogens in the European Union. Occup Environ Med.
2000 Jan;57(1):10-8

Zhu K, Levine RS, Brann EA, Hall HI, Caplan LS, Gnepp DR. Case-control study evaluating the homogeneity and heterogeneity of risk factors between sinonasal and nasopharyngeal cancers. Int J Cancer. 2002 May 1;99(1):119-23

FRANCO CANGIANI

Provenienza

Torino

Professione

Medico del Lavoro Competente

Messaggi

224

• Re: Polveri di legno
• (23/12/2010 01:39)

paraquat il 22/12/2010 07:39 ha scritto:
Vi ricordo che i tumori naso sinusali sono ad alta frazione eziologica.

Un po' di bibliografia:

Barbieri PG, Lombardi S, Candela A, Festa R. Il Registro Neoplasie Naso-sinusali della provincia di Brescia. Epidemiol Prev 2003; 27 (4): 215-220.

Demers AP, Koveginas M, Boffetta P, et al. Wood dust and sino-nasal cancer: pooled reanalysis of twelve case-control studies. Am J Ind Med, 1995, 28: 151-166.

International Agency for Research on Cancer. World Health Organization. Iarc monographs on the evaluation of carcinogenic risks to humans. Wood dust and Formaldehyde, volume 26, 1995.

Gordon I, Boffetta P, Demers PA. A case study comparing a meta-analysis and a pooled analysis of
studies of sinonasal cancer among wood workers. Epidemiology. 1998 Sep;9(5):518-24

Iaia TE, Farina G, Ferraro MT, Miceli GB, Mugnaini E, Papaleo B, Battista G. A series of cases of
sinonasal cancer among shoemakers and tannery workers Epidemiol Prev. 2004 May-
Jun;28(3):169-73

International Agency for Research on Cancer. World Health Organization. Iarc monographs on the evaluation of carcinogenic risks to humans. Chromium, Nickel and Welding, volume 49, 1990.

International Information System on Occupational Exposure to Carcinogen. Occupational exposure to carcinogens in Italy in 1990-93. Carex/draft March 19, 1998.

Leclerc A, Luce D, Demers AP, et al. Sinonasal cancer on occupation.Results from the reanalysis of twelve case-control studies. Am J Ind Med, 1997, 31: 153-165.

Luce D, Leclerc A, Begin D, Demers PA, Gerin M, Orlowski E, Kogevinas M, Belli S, Bugel I, Bolm- Audorff U, Brinton LA, Comba P, Hardell L, Hayes RB, Magnani C, Merler E, Preston-Martin S, Vaughan TL, Zheng W, Boffetta P. Sinonasal cancer and occupational exposures: a pooled analysis of 12 case-control studies. Cancer Causes Control. 2002 Mar;13(2):147-57

Mastrangelo G, Fedeli U, Fadda E, Milan G, Lange JH. Epidemiologic evidence of cancer risk in textile industry workers: a review and update. Toxicol Ind Health. 2002 May;18(4):171-81

Mirabelli D, Kauppinen T. Occupational exposures to carcinogens in Italy: an update of CAREX database. Int J Occup Environ Health. 2005 Jan-Mar;11(1):53-63

Pelausa EO, Fortier MAG. Schneiderian papillomi of the nose and paranasal sinuose: the University of Ottawa experience. J Otolaryngol 1992; 21:9-15.

Shimizu H, Hozawa J, Saito H, et al. Chronic sinusitis and woodworking as risk factors for cancer of the maxillary sinus in the northeast Japan. Laryngoscope 1989; 99: 58-61.

t’Mannetje A, Kogevinas M, Luce D, et al. Sinonasal cancer, occupation and tobacco smoking in european women and men. Am J Ind Med 1999; 36: 101-107.

Teschke K, Morgan MS, Checkoway H, Franklin G, Spinelli JJ, van Belle G, Weiss NS. Surveillance of nasal and bladder cancer to locate sources of exposure to occupational carcinogens. Occup Environ Med. 1997 Jun;54(6):443-51

Van den Oever R. Occupational exposure to dust and sinonasal cancer. An analysis of 386 cases reported to the N.C.C.S.F. Cancer Registry. Acta Otorhinolaryngol Belg. 1996;50(1):19-24

Kauppinen T, Toikkanen J, Pedersen D, Young R, Ahrens W, Boffetta P, Hansen J, Kromhout H,
Maqueda Blasco J, Mirabelli D, de la Orden-Rivera V, Pannett B, Plato N, Savela A, Vincent R,
Kogevinas M. Occupational exposure to carcinogens in the European Union. Occup Environ Med.
2000 Jan;57(1):10-8

Zhu K, Levine RS, Brann EA, Hall HI, Caplan LS, Gnepp DR. Case-control study evaluating the homogeneity and heterogeneity of risk factors between sinonasal and nasopharyngeal cancers. Int J Cancer. 2002 May 1;99(1):119-23

Bene hanno dimostrato che esiste una correlazione con esposizione a polveri di legno (duro). Ma qualche studio ha investigato anche l'utilità della sorveglianza sanitaria aziendale nella diagnosi precoce di questi tumori? Il rapporto costo beneficio per la società di sottoporre a visite mediche obbligatorie annuali per legge milioni di persone per trovare 400 cancri annui? Magari cancri che insorgono a 70-80 anni di età e dopo il pensionamento?
Quanti di questi cancri sono stati identificati in sede di visita da parte del medico competente? quei casi che sono stati identificati dal medico competente quale esito hanno avuto...sono morti o sono sopravvissuti? Di quelli denunciati quanti sono stati indennizati? Mi rimangono ancora un pò di dubbi...cmq ti ringrazio per i riferimenti bibliografici...